Author

Letizia Fontana

InsermORCID 0009-0001-8603-5188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Annarita MiccioiD· 2 shared Anne ChalumeauiD· 2 shared Guillaume CorreiD· 2 shared Margaux MomblediD· 2 shared Mario AmendolaiD· 2 shared Panagiotis AntoniouiD· 2 shared Simone AmistadiiD· 2 shared Alexandra TachtsidiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Annarita MiccioORCID

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2 papers

Recent·Most cited

Molecular BiologyCell Reports MedicinePeer-reviewedSep 27, 2025

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

Letizia Fontana, Pierre Martinucci, Simone Amistadi…·Annarita Miccio

This study uses multiplex base editing to target BCL11A enhancers, increasing fetal hemoglobin production and reducing sickle cell disease symptoms without causing significant genomic damage.

8 citationstop 4%

humanCRISPR screen

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Molecular BiologyBloodPeer-reviewedAug 26, 2025

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease

Anne Chalumeau, Maria Bou Dames, Letizia Fontana…·Mégane Brusson

This paper describes a prime editing strategy to modify γ-globin promoters in HSPCs to increase HbF expression for sickle cell disease treatment.

10 citationstop 3%

humanexperimental assay

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