Lillian B. Cohn

Haplotype and diversity signatures of ultra-soft selective sweeps in HIV-1

The paper shows HIV can adapt to antibody treatment without reducing genetic diversity, challenging methods that rely on diversity and haplotype signatures to detect resistance.

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir

The paper identifies autologous neutralizing antibodies (aNAbs) as critical determinants of HIV-1 rebound after treatment interruption, defining quantitative limits on rebound-competent reservoirs.

Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo

This study examines HIV escape from two bNAbs in vivo, identifying recurrent mutations and genetic background dependencies in viral resistance.

Early immune responses anticipate HIV rebound and precede viral control

The paper identifies early immune responses preceding HIV rebound and links them to viral control outcomes in individuals discontinuing antiretroviral treatment.

Inflammatory Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia

The paper identifies increased CD16++ monocytes with anti-viral gene expression before HIV-1 rebound, suggesting early immune signals of viral resurgence.