Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Liqiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang
This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.
Advanced Science · May 25, 2026Peer-reviewedBiochemistry