Zhong Zheng

Decoder-FFPE-seq improves sensitivity and resolution for spatial transcriptomics in FFPE tissues, enabling analysis of rare genes and tumor microenvironments.

This paper describes a transgene-free human embryo model that recapitulates peri-gastrulation development, including trilaminar embryonic disc and yolk sac-like structures.

The paper introduces WPS2, a high-throughput and high-sensitivity scRNA-seq method, which improves gene and transcript detection in low RNA-content cells and nuclei.

Decoder-seq is a spatial RNA sequencing method that provides high-resolution, cost-effective, and sensitive spatial transcriptomic analysis, revealing detailed spatial gene expression patterns in mouse hippocampus and renal cancer.

This paper introduces DR-6mA-seq, a method to detect 6mA at single-base resolution in mammalian genomes, finding low abundance in most tissues but distinct sites in mouse testis and glioblastoma cells.