Lisheng Zhang

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

This paper develops a super-resolution imaging method to quantify oxidative DNA damage at the single-cell level using DNA aptamers and DNA-PAINT, showing improved specificity and resolution over traditional methods.

This study identifies FUBP1 as an Nm-binding protein and shows it regulates splicing by binding to Nm-modified intronic regions.

This study maps pseudouridine modifications across bacterial species, revealing dynamic patterns and evolutionary conservation, and develops a deep learning framework for predicting modified sites.

This paper introduces DR-6mA-seq, a method to detect 6mA at single-base resolution in mammalian genomes, finding low abundance in most tissues but distinct sites in mouse testis and glioblastoma cells.

The paper shows RNA alkylation triggers recruitment of the ASCC repair complex via RNF113A, revealing RNA damage as a signal for DNA repair.