Yi Zheng

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

This study uses micropatterned cardioids to investigate mesoderm-endoderm interactions in heart development, finding that pattern size affects cavity formation and signaling.

A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data

The paper develops a comprehensive reference tool for human embryogenesis using integrated single-cell RNA-sequencing data to benchmark embryo models.

A transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures

This paper describes a transgene-free human embryo model that recapitulates peri-gastrulation development, including trilaminar embryonic disc and yolk sac-like structures.

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

The paper creates a cell atlas of early human peri-implantation lineages and develops an embryo-like assembloid to study lineage development and signaling mechanisms.

Viral proteins and virus-like particles of the LTR5_Hs endogenous retrovirus in human primordial germ cell-like cells

The paper identifies LTR5_Hs viral proteins and virus-like particles in hPGCLCs, showing their activation during early germ cell development and suppression upon gonadal anlagen settlement.

Amnion signals are essential for mesoderm formation in primates

The paper identifies ISL1's critical role in primate mesoderm formation through a transcriptional atlas and CRISPR experiments in non-human primates.