BTK inhibition enhances immunovirotherapy in glioblastoma via tertiary lymphoid structure modulation
Konstantina Kyritsi, Dong Zhu, Haocheng Ding, Gregory K. Friedman, Dongwen Lv, Meng Wang, Nahid F. Mivechi, Ravindra B Kolhe, Theodore S. Johnson, Balveen Kaur, David H. Munn, Bangxing Hong
This study shows that BTK inhibition enhances oncolytic virotherapy in glioblastoma by promoting tertiary lymphoid structure formation and improving immune cell infiltration.
bioRxiv · Jun 4, 2026 · PreprintCancer Biology