Developmental BiologyFrontiers in Cell and Developmental BiologyPeer-reviewed
Sonic hedgehog is essential for proximal-distal outgrowth of the limb bud in salamanders
Sruthi Purushothaman, Brianda B. Lopez Aviña, Ashley Winn Seifert
This study shows that Sonic hedgehog signaling is critical for limb development in axolotls, with loss of Shh leading to complete absence of forelimbs and highlighting a derived mode of limb development in urodeles.