Ashley Winn Seifert

The paper investigates whether actively cycling cells in uninjured tissue are necessary for regeneration, finding they are not required in four vertebrate species.

This study shows that deep tissue removal in coral wounds promotes algal colonization and inhibits healing, while scraping wounds regenerate rapidly in some coral species.

The paper identifies AAV vectors that efficiently deliver transgenes to the nervous systems of spiny mice, enabling functional studies of regeneration.

This paper identifies a unique fracture lattice in spiny mouse skin that enables controlled tissue autotomy and regeneration.

This study models Parkinson's disease in spiny mice, showing they exhibit key disease features like behavioral impairments, neuronal degeneration, and proteomic changes similar to PD.

This study compares fibroblast metabolism across species, finding spiny mice and rabbits exhibit a glycolytic preference and oxidative stress resilience across lifespan.

The paper identifies injury-induced cell states associated with regeneration in spiny mice, contrasting with fibrotic healing in mice, by analyzing proliferation dynamics and cell type-specific gene expression.

This study characterizes the development of the murid ear pinna, showing neural crest-derived cells contribute to connective tissue but not skeletal muscle or hair follicles.

This study shows that Sonic hedgehog signaling is critical for limb development in axolotls, with loss of Shh leading to complete absence of forelimbs and highlighting a derived mode of limb development in urodeles.

This study shows that spiny mice (Acomys) have better cardiac recovery after myocardial infarction compared to common lab mice, with less scarring and better function.

The paper generates a transgenic axolotl line expressing FUCCI to study cell cycle dynamics during tissue regeneration.

This study investigates salamander skin regeneration and development, finding that regeneration follows a developmental pathway distinct from direct development, requiring ECM remodeling and fibroblast activity.