Author

Sruthi Purushothaman

University of British ColumbiaORCID 0000-0002-3974-4731Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ashley Winn SeifertiD· 1 shared Brianda B. Lopez AviñaiD· 1 shared Christine EisneriD· 1 shared David R Kaplan· 1 shared Fabio M V RossiiD· 1 shared Freda D. MilleriD· 1 shared Konstantina Karamboulas· 1 shared Sandeep SaxenaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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1 shared paperDevelopmental Biology

Ashley Winn SeifertORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 22, 2026

The nail mesenchyme creates a regeneration-specific ligand environment that orchestrates mammalian regeneration versus fibrotic wound healing

Sruthi Purushothaman, Sandeep Saxena, Christine Eisner…·Freda D. Miller

The paper identifies the nail mesenchyme's role in creating a BMP-rich ligand environment that drives regeneration over fibrosis in digit tip regeneration.

DOI 10.64898/2026.04.18.719303

mousespatial transcriptomics

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Developmental BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedApr 1, 2022

Sonic hedgehog is essential for proximal-distal outgrowth of the limb bud in salamanders

Sruthi Purushothaman, Brianda B. Lopez Aviña, Ashley Winn Seifert

This study shows that Sonic hedgehog signaling is critical for limb development in axolotls, with loss of Shh leading to complete absence of forelimbs and highlighting a derived mode of limb development in urodeles.

12 citations

mousezebrafish

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