Ruiyuan Zhang

Genetic effects on serum and urine metabolites across ancestries and their links to disease

This study identifies mQTLs for serum and urine metabolites across ancestries, revealing ancestry-specific genetic effects and linking them to disease traits.

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

NicheScribe: consistent and generalizable annotation of stromal cells in the murine bone marrow niche

The paper develops NicheScribe, a method for consistently annotating stromal cells in the murine bone marrow niche using scRNA-seq data, enabling comparative analysis across different conditions.

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation

The paper identifies shared and distinct molecular mechanisms of emergency myelopoiesis using scRNA-seq and develops tools to annotate and model hematopoietic differentiation.

Glutamine addiction is a therapeutic target to block emergency myelopoiesis

This study identifies glutaminolysis as a therapeutic target to suppress emergency myelopoiesis by targeting glutaminase in hematopoietic stem and progenitor cells.