Sander Boymans

This study investigates the mutational consequences of global DNA hypomethylation by analyzing single-cell genetic variation in DNMT1-depleted cells, finding increased chromosomal instability without significant mutational burden or structural changes.

This study quantifies and characterizes mutation accumulation in human induced pluripotent stem cells and adult stem cells during in vitro culture, revealing distinct mutational signatures and higher mutation rates compared to in vivo.

Sperm DNA damage leads to genomic defects in embryos through chromosome fragmentation and segregation errors.

This study prioritizes driver genes in patients with de novo genomic structural variants using integrative analysis of WGS data, phenotype information, and chromatin organization datasets.

The paper quantifies somatic mutation accumulation in fetal liver and intestinal stem cells, finding higher mutation rates and distinct mutation spectra in fetal liver compared to fetal intestine and adult tissues.

The paper shows that NER deficiency increases Signature 8 mutations in specific tissues and suggests this could be a biomarker for NER-deficiency in cancer.