Author

Bastiaan R. Van der Roest

University Medical Center UtrechtORCID 0000-0002-8985-8964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Organism:human· 1 Assay:long-read sequencing· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Arne van HoeckiD· 2 shared Edwin P. J. G. CuppeniD· 2 shared Ruben van BoxteliD· 2 shared Alexander SchönhuthiD· 1 shared Arianne M. BrandsmaiD· 1 shared Ewart KuijkiD· 1 shared Freek MandersiD· 1 shared Jasmijn A. BaaijensiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Arne van HoeckORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MutationalPatterns: The one stop shop for the analysis of mutational processes

Freek Manders, Arianne M. Brandsma, Jurrian K. de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan R. Van der Roest, Arne van Hoeck, Edwin P. J. G. Cuppen, Ruben van Boxtel

The paper introduces an updated R/Bioconductor package for analyzing mutational patterns, demonstrating its ability to detect mutational signatures and their biological implications using simulated and real data.

BMC Genomics · Feb 15, 2022Peer-reviewedGenomics

Mutational impact of culturing human pluripotent and adult stem cells

Ewart Kuijk, Myrthe Jager, Bastiaan R. Van der Roest, Mauro D. Locati, Arne van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle J.M. Besselink, Sander Boymans, Ruben van Boxtel, Edwin P. J. G. Cuppen

This study quantifies and characterizes mutation accumulation in human induced pluripotent stem cells and adult stem cells during in vitro culture, revealing distinct mutational signatures and higher mutation rates compared to in vivo.

Nature Communications · May 19, 2020Peer-reviewedGenomics

Full-length de novo viral quasispecies assembly through variation graph construction

Jasmijn A. Baaijens, Bastiaan R. Van der Roest, Johannes Köster, Leen Stougie, Alexander Schönhuth

The paper introduces a method for full-length de novo viral quasispecies assembly using variation graphs, improving contiguity and accuracy over existing methods.

Bioinformatics · May 27, 2019Peer-reviewedBioinformatics