Janneke P. Keijer

This study shows that localized hydrogen peroxide production induces p53-dependent resistance to DNA damage, with implications for chemotherapy protection.

The paper develops a method to directly detect 8-oxo-dG using nanopore sequencing by creating synthetic DNA with context variability and training deep learning models.

This study investigates the mutational consequences of global DNA hypomethylation by analyzing single-cell genetic variation in DNMT1-depleted cells, finding increased chromosomal instability without significant mutational burden or structural changes.