Author

Zhen Yan

University at Buffalo, State University of New YorkORCID 0000-0002-3519-9596Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Zhen Yan2 papers · Carilion Clinic

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron E. Pozo‐Aranda· 1 shared Benjamin A. ReiniD· 1 shared Christine E. Schaner TooleyiD· 1 shared Elizabeth Arnulfo Candelario· 1 shared Jacob EllegoodiD· 1 shared James P. CatliniD· 1 shared Jennifer Gladys MulleiD· 1 shared Jian FengiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Aaron E. Pozo‐Aranda

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3 papers

Recent·Most cited

Cerebellar mitochondrial dysfunction coincides with structural and behavioral abnormalities in 3q29Del mice

May K Kretzer, Elizabeth Arnulfo Candelario, Ryan Montalvo, Xinyan Leng, Jonathan A. Coello, Zihui Ou, Aaron E. Pozo‐Aranda, Jacob Ellegood, Jennifer Gladys Mulle, Zhen Yan, Ryan H. Purcell, Meike E. van der Heijden

This study shows that 3q29Del mice exhibit reduced cerebellar volume, motor and vocal impairments, and mitochondrial dysfunction, mirroring human 3q29Del phenotypes.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene Smarcc2 and its Rescue by Histone Deacetylase Inhibition

Pei Li, Siqi Men, Prachetas Jai Patel, Komal Saleem, Ping Zhong, Kin Wai Tam, Jian Feng, Zhen Yan

This study shows that Smarcc2 deficiency causes cognitive and synaptic impairments in mice, which can be rescued by HDAC inhibition.

Molecular Psychiatry · Aug 26, 2026Peer-reviewedNeuroscience

Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and expansion of the neural stem cell population

James P. Catlin, Leandro N. Marziali, Benjamin A. Rein, Zhen Yan, M. Laura Feltri, Christine E. Schaner Tooley

This study shows that NRMT1 knockout mice develop neurodegeneration and cognitive impairments due to early misregulation of RB and expansion of neural stem cell populations.

bioRxiv · Mar 15, 2021 · PreprintNeuroscience