Christine E. Schaner Tooley

This study identifies Myo9b's role in regulating epithelial brush border microvilli through RhoA signaling and shows that a disease variant disrupts microvilli formation in human cells.

This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.

This paper identifies a cytoplasmic role for NRMT1 in regulating translation by interacting with ribosomal subunits and affecting mRNA selection in C2C12 mouse myoblasts.

This study shows that Nrmt1-/- mice exhibit premature aging and neurodegeneration linked to neuroinflammation due to impaired neurogenesis and lack of anti-inflammatory response.

This study shows that NRMT1 loss in C2C12 myoblasts disrupts muscle differentiation by altering gene expression related to cell cycle, muscle specification, and other lineage pathways.

This study shows that NRMT1 knockout mice develop neurodegeneration and cognitive impairments due to early misregulation of RB and expansion of neural stem cell populations.