The stereochemical mechanism of the B12-dependent radical SAM glutamine methyltransferase (QCMT): Novel insights and unprecedented post-translational modifications
Thibaut Bourdin, Alain Guillot, Mickaël Mauger, Benjamin Lefranc, Sylvain Gervason, Matthieu Glousieau, Stéphane Grimaldi, Jérôme Leprince, Aurélien Thureau, Alhosna Benjdia, Olivier Berteau
This study investigates the mechanism of QCMT, a B12-dependent radical SAM enzyme, revealing its unique catalytic properties and ability to perform novel post-translational modifications.
bioRxiv · Mar 18, 2026 · PreprintBiochemistry