Jérôme Leprince

The paper functionally characterizes 26RFa/orexin neurons in the lateral hypothalamic area and finds they regulate glucose homeostasis through coordinated neuropeptidergic signaling.

This study investigates the mechanism of QCMT, a B12-dependent radical SAM enzyme, revealing its unique catalytic properties and ability to perform novel post-translational modifications.

This study shows that Staphylococcus warneri reduces SUMOylation in intestinal cells, leading to inflammation through its toxin Warnericin RK.

This study investigates the concentration-dependent effects of ODN on neuronal spiking activity in vivo and in cultured astrocytes, revealing dual modulation via GABAAR and a non-GABAAR astrocytic receptor.

The paper introduces a framework for rational head-to-tail peptide cyclization using protein structure data, demonstrating improved conformation prediction and successful application to Nrf2 and urotensin II peptides.

This paper shows that the gliopeptide ODN, when administered after day 3 post-stroke, improves motor recovery in mice by correcting cortical excitability.

This study shows that gamma oscillations decrease in the peri-infarct cortex of mice after stroke, suggesting they could be targeted to improve functional recovery.

This study shows that octadecaneuropeptide (ODN) protects rat astrocytes from 6-hydroxydopamine-induced oxidative stress and apoptosis by enhancing antioxidant defenses and inhibiting caspase-3 activation.