Benjamin Lefranc

Functional characterization of the 26RFa/orexin neurons of the lateral hypothalamic area reveals their key role in the control of glucose homeostasis

The paper functionally characterizes 26RFa/orexin neurons in the lateral hypothalamic area and finds they regulate glucose homeostasis through coordinated neuropeptidergic signaling.

The stereochemical mechanism of the B12-dependent radical SAM glutamine methyltransferase (QCMT): Novel insights and unprecedented post-translational modifications

This study investigates the mechanism of QCMT, a B12-dependent radical SAM enzyme, revealing its unique catalytic properties and ability to perform novel post-translational modifications.

Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation

This study shows that Staphylococcus warneri reduces SUMOylation in intestinal cells, leading to inflammation through its toxin Warnericin RK.

Concentration dependent dual effect of the endozepine ODN on neuronal spiking activity

This study investigates the concentration-dependent effects of ODN on neuronal spiking activity in vivo and in cultured astrocytes, revealing dual modulation via GABAAR and a non-GABAAR astrocytic receptor.

Head-to-tail peptide cyclization: new directions and application to urotensin II and Nrf2

The paper introduces a framework for rational head-to-tail peptide cyclization using protein structure data, demonstrating improved conformation prediction and successful application to Nrf2 and urotensin II peptides.

The gliopeptide ODN, a ligand for the benzodiazepine site of GABAA receptors, boosts functional recovery after stroke

This paper shows that the gliopeptide ODN, when administered after day 3 post-stroke, improves motor recovery in mice by correcting cortical excitability.