ECSIT prevents Alzheimer's disease pathology by regulating neuronal mitochondrial ROS and mitophagy
Alice Lepelley, Lauren S. Vaughn, Agnieszka Staniszewski, Hong Zhang, Fang Du, Peter Koppensteiner, Zeljko Tomljanovic, Flávia Raquel Gonçalves Carneiro, Andrew F. Teich, Ipe Ninan, Shirley ShiDu Yan, Thomas S. Postler, Matthew S. Hayden, Ottavio Arancio, Sankar Ghosh
This study shows that ECSIT regulates neuronal mitochondrial ROS and mitophagy, and its reduction contributes to Alzheimer's disease pathology.
bioRxiv · Jan 9, 2020 · PreprintNeuroscience