Fang Du

APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction

This study shows APOE4 worsens stress hormone-induced tau pathology in the hippocampus through mitochondrial dysfunction and identifies a potential therapeutic target.

Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

This study shows that glucocorticoids promote vesicle-free Tau secretion and trans-neuronal Tau spreading in the brain, contributing to Alzheimer's disease progression.

ECSIT prevents Alzheimer's disease pathology by regulating neuronal mitochondrial ROS and mitophagy

This study shows that ECSIT regulates neuronal mitochondrial ROS and mitophagy, and its reduction contributes to Alzheimer's disease pathology.