Ottavio Arancio

This study shows that long-term locus coeruleus stimulation worsens memory, synaptic plasticity, and Tau pathology in PS19 mice.

This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.

This study shows that the 5-HT2B receptor antagonist MW073 reduces aggressive behavior in an Alzheimer's disease mouse model.

The paper investigates how PP2A regulators LCMT-1 and PME-1 affect sensitivity to tau-induced impairments in models of neurodegenerative diseases.

The paper identifies epigenetic and gene expression changes in mice exposed to prolonged low-dose Aβ42, linking them to phases of memory enhancement, transition, and decline associated with Alzheimer's disease.

The paper designs and synthesizes new activators of the p300 histone acetyltransferase enzyme to treat neurodegenerative and cancer disorders.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study shows that AAV-delivered scFv antibodies targeting Aβ oligomers protect synapses and rescue memory in Alzheimer's disease models.

This study shows that deleting α7 nicotinic acetylcholine receptors in mice leads to Alzheimer's-like pathology through increased amyloid-beta and tau abnormalities.

This study shows that ECSIT regulates neuronal mitochondrial ROS and mitophagy, and its reduction contributes to Alzheimer's disease pathology.