Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function
Tyler F. Hill, Anna E Helmers, Rene Yu-Hong Cheng, Swati Singh, Leah J. Homad, Parnal Narvekar, Gregory D. Asher, Nathan D. Camp, Emmaline R. Suchland, Andee R. Ott, Malika R. Hale, Chris Thouvenel, Claire M. Stoffers, Stefan Lachkar, Andrew T. McGuire, , Richard G. James
This study develops a humanized mouse model to evaluate engineered plasma cells and their therapeutic antibody secretion, showing long-term antibody production and neutralization of SARS-CoV-2.
Molecular Therapy Advances · Jan 9, 2026Peer-reviewedMolecular Biology