Author

Malika R. Hale

Seattle Children's Research InstituteORCID 0000-0002-0822-7141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

David J. RawlingsiD· 2 shared Andee R. OttiD· 1 shared Andrea Repele· 1 shared Andrew T. McGuireiD· 1 shared Anna E Helmers· 1 shared Chris Thouvenel· 1 shared Christopher D. ThouveneliD· 1 shared Claire M. Stoffers· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

David J. RawlingsORCID

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2 papers

Recent·Most cited

Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function

Tyler F. Hill, Anna E Helmers, Rene Yu-Hong Cheng, Swati Singh, Leah J. Homad, Parnal Narvekar, Gregory D. Asher, Nathan D. Camp, Emmaline R. Suchland, Andee R. Ott, Malika R. Hale, Chris Thouvenel, Claire M. Stoffers, Stefan Lachkar, Andrew T. McGuire, , Richard G. James

This study develops a humanized mouse model to evaluate engineered plasma cells and their therapeutic antibody secretion, showing long-term antibody production and neutralization of SARS-CoV-2.

Molecular Therapy Advances · Jan 9, 2026Peer-reviewedMolecular Biology

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

Malika R. Hale, Kennidy K. Takehara, Christopher D. Thouvenel, Dina A. Moustafa, Andrea Repele, Mary F. Fontana, Jason Netland, Sharon McNamara, Ronald L. Gibson, Joanna B. Goldberg, David J. Rawlings, Marion Pepper

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

eLife · Apr 24, 2025Peer-reviewedImmunology