Nathan D. Camp

An integrated, scaled approach to resolve TSC2 variants of uncertain significance

Abundance scores for 8,891 TSC2 missense variants, plus mTOR pathway activity scores for 391, were calibrated to ACMG/AMP evidence. They putatively reclassify 212 of 276 clinical-cohort missense VUS.

Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function

This study develops a humanized mouse model to evaluate engineered plasma cells and their therapeutic antibody secretion, showing long-term antibody production and neutralization of SARS-CoV-2.

Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data

The paper introduces a computational method to identify missing signaling pathway elements from temporal phosphoproteomic data, demonstrating its effectiveness in both human EGF response and yeast osmotic stress response.