Author

Seraina Oberli

University of ZurichORCID 0000-0002-3568-7637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

George D. LampeiD· 2 shared Giada FinocchioiD· 2 shared Martin JínekiD· 2 shared Samuel H. SternbergiD· 2 shared Iana HammerschmidiD· 1 shared Irma QuerquesiD· 1 shared Julia KaraniD· 1 shared Mateusz WalteriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

George D. LampeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases

Mateusz Walter, Giada Finocchio, Seraina Oberli, Iana Hammerschmid, George D. Lampe, Julia Karan, Thomas Swartjes, Samuel H. Sternberg, Martin Jínek, Irma Querques

This study investigates the mechanism of transposon excision by type I-F CRISPR-associated transposases using structural and biochemical analyses.

Nature Communications · Aug 24, 2026Peer-reviewedBiochemistry

Structural basis of RNA-guided DNA integration by type I CRISPR-associated transposases

Giada Finocchio, Seraina Oberli, George D. Lampe, Michael Schmitz, Samuel H. Sternberg, Martin Jínek

This study uses cryo-EM to reveal the structural mechanism of RNA-guided DNA integration by PseCAST, providing insights for engineering DNA insertion systems.

bioRxiv · May 18, 2026 · PreprintMolecular Biology