Paloma Navarro Negredo

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

The paper develops spatial aging clocks to analyze cell proximity effects in mouse brain aging and rejuvenation, revealing pro-aging and pro-rejuvenating influences of specific cell types.

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

TISSUE improves spatial transcriptomics analysis by providing uncertainty-calibrated predictions, enhancing downstream tasks like clustering and differential expression analysis.

The paper investigates chromatin accessibility changes in neurogenic niche cells during aging, identifying defects in NSC adhesion and migration and proposing ROCK inhibition as a potential therapeutic strategy.