Ahmet Saçan

The paper shows that macrophage-derived sEVs reduce inflammatory pain by reprogramming microglial epigenetic memory, specifically through H3K4me1 enrichment and SETD7 inhibition.

Azurify classifies somatic variants' clinical significance using machine learning and integrates with clinical data, achieving high accuracy in external validation.

IMMUNOTAR prioritizes and identifies immunotherapeutic targets by integrating RNA-sequencing and proteomics data with public databases to evaluate surface proteins across diverse criteria.

This study shows that morphine alters miRNA composition in small extracellular vesicles, which may influence pain responses and suggest sEVs as a potential non-opioid therapeutic.

The paper shows that cohesin loading from Vβ promoters or enhancers initiates loop extrusion across the Tcrb locus, enabling long-range recombination.

This study shows that mouse serum-derived small extracellular vesicles can reduce inflammatory pain through opioid signaling and immunomodulation.

This study identifies genes under selection in chimpanzee subspecies at a contact zone, linking environmental variation to genetic divergence and adaptation.