Promoter- and Enhancer-Dependent Cohesin Loading Initiates Chromosome Looping to Fold Tcrb Loci for Long-Range Recombination
Brittney M. Allyn, Katharina E. Hayer, Clément Oyeniran, Vincent K. Nganga, Kyutae David Lee, Ahmet Saçan, Eugene M. Oltz, Craig H. Bassing
The paper shows that cohesin loading from Vβ promoters or enhancers initiates loop extrusion across the Tcrb locus, enabling long-range recombination.
bioRxiv · Oct 13, 2024 · PreprintMolecular Biology