Seena K. Ajit

The paper shows that macrophage-derived sEVs reduce inflammatory pain by reprogramming microglial epigenetic memory, specifically through H3K4me1 enrichment and SETD7 inhibition.

This study shows that macrophage-derived extracellular vesicles promote inflammatory pain resolution via T cell-dependent immune mechanisms in mice.

This study shows that morphine alters miRNA composition in small extracellular vesicles, which may influence pain responses and suggest sEVs as a potential non-opioid therapeutic.

This study shows that mouse serum-derived small extracellular vesicles can reduce inflammatory pain through opioid signaling and immunomodulation.