Hiroshi Akazawa

Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk

This paper identifies new genetic loci for atrial fibrillation through a trans-ancestry meta-analysis and develops a polygenic risk score linked to cardioembolic risk.

Deep learning-based chest X-ray age serves as a novel biomarker for cardiovascular aging

This paper develops a deep learning model to estimate patient age and sex from chest X-rays, finding that CXR age correlates with cardiovascular aging and disease outcomes.

Transethnic meta-analysis of genome-wide association studies identifies three new loci and characterizes population-specific differences for coronary artery disease

This study identifies three new CAD loci through transethnic GWAS and highlights population-specific genetic differences between Japanese and European populations.

Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease

This study identifies novel genetic loci for coronary artery disease in Japanese and transethnic populations and develops a polygenic risk score that outperforms population-specific scores.

PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3+ Regulatory T cells

The paper identifies a PTGER2-β-catenin axis that balances IFNγ and IL-10 in FoxP3+ Tregs, linking high salt environments to autoimmunity.