Author

Margarita Dominguez‐Villar

Imperial College LondonORCID 0000-0002-9719-0028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Abdulrahman Al-MohammadiD· 1 shared Adriana SimizoiD· 1 shared Adriel Leal NóbileiD· 1 shared Allison K. MaheriD· 1 shared Anny Silva AdriiD· 1 shared Antonio ScalfariiD· 1 shared Atsuhiko T. Naito· 1 shared Benjamin H. L. HarrisiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Abdulrahman Al-MohammadORCID

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Author profile →

4 papers

Recent·Most cited

HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity

Fernando Yuri Nery do Vale, Carlota Miranda-Solé, Adriel Leal Nóbile, Júlia Nakanishi Usuda, Dennyson Leandro M. Fonseca, Lena F. Schimke, Mauro César Cafundó Morais, Débora Gomes de Albuquerque Freitas, Anny Silva Adri, Roseane Galdioli Nava, Yohan Lucas Gonçalves Corrêa, Hugo Fernando Nery do Vale, Adriana Simizo, Niels Olsen Saraiva Câmara, Gustavo Cabral‐Miranda, , Otávio Cabral-Marques

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

bioRxiv · Mar 12, 2026 · PreprintMolecular Biology

Accelerated memory T cell decline and tolerogenic recall responses to SARS-CoV-2 vaccination in diabetes

Emma M Jones, Caren Sourij, Martin Helmut Stradner, Peter Schlenke, Nazanin Sereban, Othmar Moser, Rachael A. Quinlan, Charlotte-Eve S. Short, Benjamin H. L. Harris, Michael Barry Fertleman, Graham Philip Taylor, Nick S. Oliver, Harald Sourij, Margarita Dominguez‐Villar

This study examines T cell responses to SARS-CoV-2 vaccination in people with type 1 and type 2 diabetes, finding impaired memory maintenance and tolerogenic recall responses compared to non-diabetic individuals.

bioRxiv · Feb 8, 2025 · PreprintImmunology

Sphingosine-1-phosphate signaling inhibition suppresses Th1-like Treg generation by reversing mitochondrial uncoupling

Rachel Coulombeau, Claudia Selck, Nicolas Giang, Abdulrahman Al-Mohammad, Natalie Ng, Allison K. Maher, Rafael José Argüello, Antonio Scalfari, James A. Varley, Richard S. Nicholas, Margarita Dominguez‐Villar

This study shows that inhibiting S1P signaling with FTY720 suppresses Th1-like Treg generation and restores their suppressive function by reversing mitochondrial uncoupling.

Immunology · Oct 24, 2024Peer-reviewedImmunology

PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3+ Regulatory T cells

Tomokazu Sumida, Matthew R. Lincoln, Chinonso M. Ukeje, Donald M. Rodriguez, Hiroshi Akazawa, Tetsuo Noda, Atsuhiko T. Naito, Issei Komuro, Margarita Dominguez-Villar, David A. Hafler

The paper identifies a PTGER2-β-catenin axis that balances IFNγ and IL-10 in FoxP3+ Tregs, linking high salt environments to autoimmunity.

bioRxiv · Aug 2, 2018 · PreprintImmunology