Seitaro Nomura

Hox-Meis-relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

Bioengineered iPSC Vessels Recapitulate Human Vascular Physiological Function and Aging Phenotypes

This paper develops a human vascular model using iPSC-derived cells that mimics vascular aging phenotypes and responds to vasoactive stimuli, showing potential for aging research and drug discovery.

Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis

The paper uses multimodal analysis to reveal cardiac neural crest lineage diversity and gene regulatory networks involved in their differentiation.

Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk

This paper identifies new genetic loci for atrial fibrillation through a trans-ancestry meta-analysis and develops a polygenic risk score linked to cardioembolic risk.

Transethnic meta-analysis of genome-wide association studies identifies three new loci and characterizes population-specific differences for coronary artery disease

This study identifies three new CAD loci through transethnic GWAS and highlights population-specific genetic differences between Japanese and European populations.

Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease

This study identifies novel genetic loci for coronary artery disease in Japanese and transethnic populations and develops a polygenic risk score that outperforms population-specific scores.