Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors
Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, , Kazuto Kobayashi
This paper develops a method to activate specific neurons in the mammalian brain using peripheral administration of ligand precursors, demonstrating its effectiveness in inducing neurotransmitter release and behavioral responses.
bioRxiv · Sep 11, 2023 · PreprintNeuroscience