Hiroshi Mizuma

Single MAPT knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors

This paper develops a method to activate specific neurons in the mammalian brain using peripheral administration of ligand precursors, demonstrating its effectiveness in inducing neurotransmitter release and behavioral responses.

Enhanced aversive memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

This study shows that activating locus coeruleus norepinephrine neurons enhances aversive memory retrieval in mice.