ImmunologyNaturePeer-reviewed
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
Samarth Hegde, Bruno Giotti, Brian Y. Soong…·Miriam Mérad
The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.