Author
Icahn School of Medicine at Mount SinaiORCID 0000-0002-1943-5173Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Mekenzie Peshoff, Tanvi Joshi, Darwin D’souza…·Long‐Jun Wu
This study shows TREM2's role in glioblastoma depends on genetic context and timing, with different effects in Nf1-silenced/Ras-driven and PDGFB-driven models.
Raphaël Mattiuz, Jesse Boumelha, Emmanouil Aerakis…·Miriam Mérad
This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.
William Pilcher, Lijun Yao, Edgar Gonzalez‐Kozlova…·Manoj Bhasin
The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.
Samarth Hegde, Bruno Giotti, Brian Y. Soong…·Miriam Mérad
The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.
Pauline Hamon, Matthew D. Park, Jessica Le Bérichel…·Miriam Mérad
The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.
Alexander C. Bashore, Emir Radkevich, Vladimir Roudko…·Amy Kontorovich
This study identifies 25 cellular subsets in thoracic aortic aneurysm tissue and links FGF-23 as a plasma biomarker associated with aortic diameter and disease.
Francesca Cossarini, Joan Shang, Azra Krek…·Saurabh Mehandru
Emir Radkevich, Darwin D’souza, Raphaël Mattiuz…·Vladimir Roudko
The paper benchmarks deconvolution tools for spatial transcriptomic data and introduces a novel pipeline to analyze tissue microenvironment dynamics.