Dhawal S. Jain

Minuteman provides a secure cloud platform for collaborative biomedical data analysis with features for data management, access control, and interactive exploration.

SciViewer is an interactive tool for visualizing and analyzing single-cell datasets, offering target-centric views and integration with pharmacogenomics databases.

This study identifies a network of histone chaperones and elongation factors that coordinate transcriptional accuracy and chromatin structure through their physical interactions.

HiTea uses Hi-C data to detect non-reference transposable element insertions, outperforming whole genome sequencing-based methods in human cell lines.

This study shows that Spn1 is essential for normal mRNA levels, splicing of ribosomal protein transcripts, and histone modifications in yeast.

This study investigates how WT1-mediated transcriptional reprogramming responds to podocyte injury, revealing a repair mechanism that is later suppressed as injury progresses.

HiNT detects copy number variations and translocations from Hi-C data with single base-pair resolution, outperforming existing methods on simulated and real data.

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.

The paper identifies genome-wide phased nucleosome arrays in Drosophila, revealing a novel sequence motif and the role of the zinc finger protein Phaser in their formation.

This study shows that ACF1-containing chromatin remodeling complexes repress gene expression by maintaining a repressive chromatin state in Drosophila.