Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decay
Lisa Fish, Albertas Navickas, Bruce Culbertson, Yichen Xu, Hoang C.B. Nguyen, Steven Zhang, Myles Hochman, Ross A. Okimoto, Brian D. Dill, Henrik Molina, Hamed Shateri Najafabadi, Claudio R. Alarcón, Davide Ruggero, Hani Goodarzi
The paper identifies TARBP2 as a nuclear RNA-binding protein that regulates transcript stability through m6A methylation, splicing inhibition, and exosome-mediated degradation, with implications for lung cancer progression.
Molecular Cell · Jul 9, 2019Peer-reviewedMolecular Biology