Ross A. Okimoto

The paper develops synthetic CIC-family fusion oncoproteins to study their distinct transcriptional effects in cancer.

This study shows that the C1 domain of CIC is required for full activity of the CIC::DUX4 fusion oncoprotein, highlighting the importance of breakpoint location in fusion function.

The paper identifies TARBP2 as a nuclear RNA-binding protein that regulates transcript stability through m6A methylation, splicing inhibition, and exosome-mediated degradation, with implications for lung cancer progression.