Davide Ruggero

NOVA: a novel R-package enabling multi-parameter analysis and visualization of neural activity in MEA recordings

NOVA is an R-package for analyzing MEA data, offering dimensionality reduction, clustering, and trajectory mapping, revealing network burst duration as a key activity metric.

Programmable translational inhibition by a molecular glue-oligonucleotide conjugate

This paper develops RocASO, a molecular glue-oligonucleotide conjugate that selectively inhibits mRNA translation by targeting specific sequences, showing potent antiviral activity against SARS-CoV-2.

Functional screen for mediators of onco-mRNA translation specificity

The paper identifies RBM42 as a key regulator of MYC translation in PDAC, showing its role in oncogenic transcript regulation and tumor growth.

RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages

RAPIDASH enriches ribosome-associated proteins from diverse samples, revealing their roles in neurodevelopment and immune response.

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs in vertebrates

The paper investigates the evolutionary retention of ribosomal protein paralogs eS27 and eS27L by showing their subfunctionalized expression patterns are necessary for maintaining total protein expression across cell types.

Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration

This study identifies mTOR-mediated translational activation as a key mechanism for rapid wound closure and regeneration in axolotls, distinct from non-regenerative mammals.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

This study identifies a p53-dependent translational program that explains tissue-selective phenotypes in ribosomopathies by regulating 4E-BP1 and altering the translatome.

Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decay

The paper identifies TARBP2 as a nuclear RNA-binding protein that regulates transcript stability through m6A methylation, splicing inhibition, and exosome-mediated degradation, with implications for lung cancer progression.