ImmunologyScience ImmunologyPeer-reviewed
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
Benjamin Klein, Mack B. Reynolds, Bin Xu…·Joanne Michelle Kahlenberg
The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.
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