Author

Mack B. Reynolds

Salk Institute for Biological StudiesORCID 0000-0002-8445-3749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christian M. MetalloiD· 2 shared Emeline JouliaiD· 2 shared Gerald S. ShadeliD· 2 shared Alexander Thomas WilliamsiD· 1 shared Alfredo Lucas· 1 shared Annalise BondiD· 1 shared Aurélie LaguerreiD· 1 shared Austin KangiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Christian M. MetalloORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-10/ACOD1 axis regulates catabolism of phagocytosed lipids in trained macrophages

Mack B. Reynolds, Annalise Bond, Emily M.J. Fennell, Kym J. Grae, Emeline Joulia, Matthew P. Donnelly, Melissa A. Johnson, Aurélie Laguerre, Gladys R. Rojas, Matthew J. Kolar, Janelle S. Ayres, Christian M. Metallo, Gerald S. Shadel

This study identifies an IL-10/ACOD1 axis that reprograms lipid metabolism in trained macrophages to promote resolution of inflammation.

bioRxiv · Aug 23, 2026 · PreprintImmunology

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

Raffaella Lucciola, Joseph R. Herdy, Yatavee Vajaphattana, Lukas Karbacher, Thaís S. Sabedot, Michael S. Cuoco, Larissa Traxler, Austin Kang, Mack B. Reynolds, Jeffrey R. Jones, Simon T. Schafer, Jérôme Mertens, Fred H. Gage

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

bioRxiv · Apr 14, 2026 · PreprintNeuroscience

In vivo itaconate tracing reveals degradation pathway and turnover kinetics

Hanna F Willenbockel, Alexander Thomas Williams, Alfredo Lucas, Mack B. Reynolds, Emeline Joulia, Maureen L. Ruchhoeft, Birte Dowerg, Pedro Cabrales, Christian M. Metallo, Thekla Cordes

This study uses mass spectrometry and in vivo 13C tracing to show itaconate is rapidly cleared from plasma, excreted in urine, and metabolized in the liver and kidneys.

Nature Metabolism · Sep 10, 2025Peer-reviewedCell Biology

Multi-site phosphorylation of BCL2L13 in a TBK1- and AMPK-dependent manner reveals new modes of mitophagy regulation

Hoda Ahmed, Mack B. Reynolds, Gary M. Kasof, Gerald S. Shadel, Reuben J. Shaw

This study identifies phosphorylation sites in BCL2L13 regulated by AMPK and TBK1, revealing a novel mechanism for mitophagy regulation.

bioRxiv · Jul 10, 2025 · PreprintCell Biology

Non-canonical activation of IRE1a during Candida albicans infection enhances macrophage fungicidal activity

Michael J. McFadden, Mack B. Reynolds, Britton C Michmerhuizen, Einar Birnir Olafsson, Faith M. Anderson, Tracey L. Schultz, Mary X O’Riordan, Teresa R. O’Meara

This study shows that Candida albicans activates IRE1 in macrophages through non-canonical mechanisms, enhancing fungicidal activity by promoting phagolysosomal fusion.

bioRxiv · Oct 2, 2023 · PreprintMolecular Biology