Feiyang Ma

Aberrant oxidative metabolism selects for TET2-deficient hematopoietic stem and progenitor cells

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

TREM2+ macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth

This study identifies TREM2+ lipid-laden macrophages in alveolar TB pneumonia that support Mtb survival, contrasting with granulomas, and shows pharmacological reversal of this immunometabolic state.

Cross-disease comparison of dermatomyositis and lupus skin identifies inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis

This study compares dermatomyositis and lupus skin lesions using single-cell RNA-sequencing to identify inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

Resolving the design principles that control postnatal vascular growth and scaling

The paper identifies biological principles governing postnatal aortic growth, showing it scales with the vertebral column and relies on differentiated cell proliferation rather than stem cells.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration

The paper identifies heterogeneous pdgfrβ+ cells critical for coronary vessel development and heart regeneration in zebrafish.

Transcriptional evaluation of the ductus arteriosus at the single-cell level uncovers a requirement for vimentin for complete closure

The paper uses single-cell RNA sequencing to study ductus arteriosus closure in mice, identifying vimentin as critical for vascular remodeling and closure.

Systematic evaluation of transcriptomics-based deconvolution methods and references using thousands of clinical samples

This study evaluates ten deconvolution tools on 4,000 clinical and synthetic samples, finding EPIC performs best on Framingham data and HPCA references are generally accurate.

The Gene Expression Deconvolution Interactive Tool (GEDIT): Accurate Cell Type Quantification from Gene Expression Data

GEDIT estimates cell type abundances from gene expression data, outperforming existing tools across multiple platforms and tissue types.

Single-Cell RNA Sequencing of Batch Chlamydomonas Cultures Reveals Heterogeneity in their Diurnal Cycle Phase

Single-cell RNA sequencing reveals that heterogeneity in Chlamydomonas bulk cultures is largely driven by diurnal cycle phases.

Automated identification of Cell Types in Single Cell RNA Sequencing

ACTINN is a neural network that automatically identifies cell types in scRNA-seq data by learning features from annotated datasets, outperforming manual methods in speed and accuracy.

DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)

The paper introduces MREBS, a method for DNA methylation estimation that reduces sequencing costs while improving coverage compared to existing methods.