Noa Chapal-Ilani

Circulating hematopoietic stem and progenitor cells in myeloproliferative neoplasms

This study profiles circulating hematopoietic stem and progenitor cells in MPN patients, identifying transcriptional signatures and quantitative readouts to distinguish MF from other MPNs and predict progression.

DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

Natural and age-related variation in circulating human hematopoietic stem cells

The paper characterizes age-related and inter-individual variation in circulating hematopoietic stem cells and establishes a normal reference to identify hematological disorders.

DNA Methylation is stable after MMEJ and NHEJ double strand break repair

The paper examines DNA methylation stability after MMEJ and NHEJ repair mechanisms, finding that methylation levels remain stable despite repair-induced deletions and in the presence of a DNMT3A mutation.

Retrospective cell lineage reconstruction in Humans using short tandem repeats

This paper introduces a method to reconstruct human cell lineages using STR mutations and demonstrates its application on melanoma and DU145 cell lines.

Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

The paper identifies microhomology-mediated end joining (MMEJ) as the mechanism behind recurrent deletions in myeloid malignancies and shows that these deletions occur in multipotent hematopoietic stem cells.

Short Tandem Repeat stutter model inferred from direct measurement of in vitro stutter noise

The paper develops a Markov model to predict STR stutter noise from direct in vitro measurements, improving genotyping accuracy in single-cell and targeted-enrichment contexts.