Yoni Moskovitz

This study investigates how DNMT3A-R882 mutations affect HSC differentiation into immune cells, finding they drive dysfunctional neutropoiesis linked to immune dysregulation and inflammatory disease risk.

The paper examines DNA methylation stability after MMEJ and NHEJ repair mechanisms, finding that methylation levels remain stable despite repair-induced deletions and in the presence of a DNMT3A mutation.

The paper identifies microhomology-mediated end joining (MMEJ) as the mechanism behind recurrent deletions in myeloid malignancies and shows that these deletions occur in multipotent hematopoietic stem cells.