Biochemistrynpj Drug Discovery.Peer-reviewed
Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11
Isabella E Jacobsen, Rui Shi, Cole R. Scholtz…·Gunda I. Georg
This paper designs a PROTAC that recruits the tissue-specific E3 ligase MAGEA11 to degrade BET proteins in cancer cells, showing selectivity in osteosarcoma and esophageal squamous cell carcinoma lines.
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