Author

William C. K. Pomerantz

University of MinnesotaORCID 0000-0002-0163-4078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 1

Frequent Co-Authors

Molly SneddoniD· 2 shared Anang A. ShelatiD· 1 shared Chi-Ming TsouiD· 1 shared Cole R. ScholtziD· 1 shared Gunda I. GeorgiD· 1 shared Isabella E JacobseniD· 1 shared Joseph E. McPhersoniD· 1 shared Kerstin E. PetersoniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Molly SneddonORCID

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3 papers

Recent·Most cited

Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11

Isabella E Jacobsen, Rui Shi, Cole R. Scholtz, William C. K. Pomerantz, Gunda I. Georg

This paper designs a PROTAC that recruits the tissue-specific E3 ligase MAGEA11 to degrade BET proteins in cancer cells, showing selectivity in osteosarcoma and esophageal squamous cell carcinoma lines.

npj Drug Discovery. · Oct 26, 2026Peer-reviewedBiochemistry

Bivalent Inhibitor Development for a Dynamic Epigenetic Tandem Reader Protein Using a Combinatorial Histone Code

Joseph E. McPherson, Molly Sneddon, Richard Kofi Begyinah, Kesavan Babu, Kerstin E. Peterson, Ryan F. Friess, Thomas G. Smith, Natalia Y. Tretyakova, Marcus M. Fischer, William C. K. Pomerantz

This study identifies H3K4me3K14ac as the specific histone modification recognized by BPTF's PHD BRD cassette, designs a bivalent inhibitor MJ-1, and provides structural insights for therapeutic development.

bioRxiv · Oct 16, 2026 · PreprintBiochemistry

NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells

Molly Sneddon, Chi-Ming Tsou, Xiang Fu, Anang A. Shelat, William C. K. Pomerantz

The paper develops a NanoBRET tracer, MS-1, to assess functional activity of class I bromodomain inhibitors in live cells, showing broad applicability across BPTF, PCAF, GCN5, and CECR2.

Bioconjugate Chemistry · Mar 4, 2026Peer-reviewedBiochemistry