Quan Shi

The paper proposes a molecular assessment strategy using transcriptomic and cytokine profiling to evaluate fetal bovine serum (FBS) performance, showing that molecular profiling is more reliable than geographical origin or CoA parameters.

The paper introduces a spatial dissimilarity method to analyze single-cell and spatial transcriptomics data, identifying alternative splicing and allele-specific gene expression in various cell types.

The DNBelab C4 portable, negative-pressure microfluidic device performs high-throughput single-cell transcriptome profiling, resolving species-specific cells and tissue heterogeneity in murine lung and cerebral cortex comparably to existing platforms.

This study demonstrates the feasibility of whole genome sequencing of fetal genomes from amniotic fluid, revealing additional genetic and clinical information beyond chromosomal abnormalities.