The human AMPKgamma3 R225W mutation does neither enhance basal AMPKgamma3-associated activity nor glycogen in human or mouse skeletal muscle
Nicolas O. Eskesen, Rasmus Kjøbsted, Jesper B. Birk, Nicolai S. Henriksen, Nicoline R. Andersen, Stine Ringholm, Henriette Pilegaard, Christian K. Pehmøller, Jørgen F. P. Wojtaszewski
This study investigates the AMPKgamma3 R225W mutation in human and mouse skeletal muscle, finding no increase in basal activity or glycogen levels, but loss of activation by AICAR/muscle contraction.
bioRxiv · Aug 28, 2023 · PreprintMolecular Biology